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Date: 10 Mar 2007 03:44:51
From:
Subject: EPO use can cause.....DEATH!!!!
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http://www.bloomberg.com/apps/news?pid=20601087&sid=aqLc.tP3A6AI&refer=home
Amgen's, J&J's Anemia Drugs Get Stronger U.S. Warning (Update4)
By Luke Timmerman
ch 9 (Bloomberg) -- The anemia drugs Aranesp and Epogen, made by
Amgen Inc., and Procrit, sold by Johnson & Johnson, will get stronger
warnings about serious health risks including death, the U.S. Food and
Drug Administration said.
The FDA also said today it is ``re-evaluating'' the safety of the
drugs. The agency is telling doctors to use the lowest doses needed to
help patients avoid blood transfusions, said Richard Pazdur, the head
of the FDA's cancer drug office, in a news conference.
``There are many questions that need to be looked at, including
additional clinical trials,'' Pazdur said.
Aranesp is Amgen's biggest-selling product, generating $4.12 billion
for the Thousand Oaks, California-based biotechnology company last
year. Aranesp and Epogen together accounted for 47 percent of the
company's revenue in 2006. Procrit, Johnson & Johnson's version of
Epogen, had $3.18 billion in sales.
Shares of Amgen fell $1.31, or 2.1 percent, to $60.86 at 4 p.m. in
Nasdaq Stock ket composite trading. Shares of Johnson & Johnson,
based in New Brunswick, New Jersey, gained 42 cents to $62.14 in New
York Stock Exchange composite trading.
Anemia drugs are the ``largest and most lucrative ket in biotech,''
and sales are growing at least 6 percent to 8 percent a year, said
Jason Kantor, an analyst with RBC Capital kets, in a January
research report. The drugs are used to treat anemia, mostly for people
with kidney disease and cancer patients undergoing chemotherapy.
Study Findings
Studies found that higher-than-approved doses of the drugs targeted by
the FDA increased the risk of death, blood clots, strokes and heart
attacks in those with chronic kidney failure, the agency said. Excess
doses led to rapid tumor growth in people with head and neck cancer.
The drugs are usually prescribed to boost levels of hemoglobin in the
blood to 12 grams a deciliter, the approved dose. Doctors may now want
to go ``no higher'' than 10 or 11 grams per deciliter, Pazdur said.
``If the target for hemoglobin is in the 10-range, then that's
definitely going to have an impact for Amgen,'' said Bill Tanner, an
analyst with Leerink Swann in New York, in a telephone interview.
Tanner's firm has done consulting for Amgen in the past year, and he
doesn't own any shares.
Epogen is the single biggest drug expense for Medicare, the U.S.
health plan for the elderly and disabled. Members of Congress have
urged Medicare to change the way it pays for the medicine to eliminate
incentives for giving higher doses.
`More is Better'
``This idea that `if some is good, more is better' is an unfortunate
theme that runs across American medicine,'' Peter Eisenberg, a cancer
physician in in County, California, said in a telephone interview.
``The more stuff we doctors sell, the more money we make. That's
another problem.''
The drugs are also used by some cancer patients not on chemotherapy.
Use of Aranesp for that purpose was removed in February from a list
that Medicare and insurers follow for reimbursement. Analysts estimate
that as much as $500 million a year of Aranesp sales come from that
use.
The contractor for Medicare in Northern California, Illinois,
Massachusetts, Maine and Vermont today stopped paying for Aranesp for
cancer patients not in chemotherapy. Medicare often influences
coverage decisions of private insurers.
Medicare pays close attention to FDA safety warnings, said Leslie
Norwalk, acting administrator of the Centers for Medicare and Medicaid
Services, in a statement. ``We will carefully examine our policies for
coverage'' of anemia drugs.
Company Responses
Amgen said in a statement that new information accompanying Aranesp
and Epogen will urge doctors to let patients know of the ``increased
risks of mortality'' when the drug is given in ways that are not FDA-
approved.
The company plans to update its keting materials to reflect the new
warnings, said Trish Hawkins, a company spokeswoman. Amgen's anemia
drugs are used by about 250,000 cancer patients a year, Hawkins said.
``Patient safety is unquestionably our top priority,'' said Roger
Perlmutter, Amgen's head of research and development, in a statement.
Ortho Biotech, the Johnson & Johnson unit that kets Procrit, also
will change its information for physicians to include the new
information, said spokeswoman Stephanie Fagan.
``It is too early to speculate'' on the financial impact of the FDA
warning, Fagan said.
Class of Drugs
The FDA's renewed scrutiny will apply across the class of drugs to
which Aranesp, Epogen and Procrit belong. The treatments are
genetically engineered forms of the protein erythropoietin, which is
made by the kidney and increases the number of red blood cells.
Roche Holding AG is attempting to develop a rival product in the
class, Cera, and has applied for FDA approval.
The FDA will hold a meeting of cancer experts on May 10 to seek advice
on the drugs, Pazdur said.
Epogen was first approved by the FDA in 1989, and became Amgen's first
big-selling drug. Procrit is sold by Johnson & Johnson under a
keting agreement with Amgen. Aranesp, a drug modified for less-
frequent dosing, was approved in 2001. The FDA said it revised the
warning labels on the products in 1997, 2004 and 2005 when new
information about safety came to light.
Procrit TV commercials in 2001 told consumers the drug could boost
their energy and provide ``strength for living.'' The camera showed an
elderly woman, who at first was too tired to sew her daughter's
wedding dress, dancing at the wedding thanks to Procrit, according to
an article in the FDA's consumer magazine.
Ortho Biotech stopped running the TV ads two years ago, Fagan said.
To contact the reporter on this story: Luke Timmerman in San Francisco
ltimmerman@bloomberg.net .
Last Updated: ch 9, 2007 18:28 EST
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Date: 11 Mar 2007 17:55:53
From:
Subject: Re: EPO use can cause.....DEATH!!!!
|
On 11, 12:18=EF=BF=BDpm, MagillaGorilla <MagillaGori...@zoo.com > wrote:
> dupedcycl...@aol.com wrote:
> >http://www.bloomberg.com/apps/news?pid=3D20601087&sid=3DaqLc.tP3A6AI&ref=
e=2E..
>
> > Amgen's, J&J's Anemia Drugs Get Stronger U.S. Warning (Update4)
>
> SNIP
>
> If the risk for death were so serious, surely we would have seen some
> pro cyclist die from it. =A0We haven't.
>
> Thanks,
>
> Magilla
Magilla
Not sure if you are fishing, but many have died...... starting with
1989 amateur world chump.
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Date: 12 Mar 2007 03:05:00
From: Michael Press
Subject: Re: EPO use can cause.....DEATH!!!!
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In article
<1173660953.423808.152210@q40g2000cwq.googlegroups.com >,
dupedcyclist@aol.com wrote:
> On 11, 12:18?pm, MagillaGorilla <MagillaGori...@zoo.com> wrote:
> > dupedcycl...@aol.com wrote:
> > >http://www.bloomberg.com/apps/news?pid=20601087&sid=aqLc.tP3A6AI&refe...
> >
> > > Amgen's, J&J's Anemia Drugs Get Stronger U.S. Warning (Update4)
> >
> > SNIP
> >
> > If the risk for death were so serious, surely we would have seen some
> > pro cyclist die from it. ?We haven't.
> >
> > Thanks,
> >
> > Magilla
>
> Magilla
>
> Not sure if you are fishing, but many have died...... starting with
> 1989 amateur world chump.
Yes, and you struck the line, candyass.
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Date: 11 Mar 2007 21:40:36
From: MagillaGorilla
Subject: Re: EPO use can cause.....DEATH!!!!
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dupedcyclist@aol.com wrote:
> On 11, 12:18�pm, MagillaGorilla <MagillaGori...@zoo.com> wrote:
>
>>dupedcycl...@aol.com wrote:
>>
>>>http://www.bloomberg.com/apps/news?pid=20601087&sid=aqLc.tP3A6AI&refe...
>>
>>>Amgen's, J&J's Anemia Drugs Get Stronger U.S. Warning (Update4)
>>
>>SNIP
>>
>>If the risk for death were so serious, surely we would have seen some
>>pro cyclist die from it. �We haven't.
>>
>>Thanks,
>>
>>Magilla
>
>
> Magilla
>
> Not sure if you are fishing, but many have died...... starting with
> 1989 amateur world chump.
>
Yeah, you got the coroner's full report and toxicology results on that
right? Or are you just repeating rumors you heard and claiming they are
the same as an actual toxicology report? (Hint: no coronor tests for EPO).
For all I know they could have died from a myriad of other substances.
You want it to be EPO so you say it is EPO. That doesn't make it so.
If you want to invent your own cause of death, then go right ahead. But
don't come in here and try to sell me on the bullshit you know it's due
to EPO when the fact is you don't.
Thanks,
Magilla
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Date: 12 Mar 2007 08:17:45
From: Kyle Legate
Subject: Re: EPO use can cause.....DEATH!!!!
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MagillaGorilla wrote:
>
> For all I know they could have died from a myriad of other substances.
> You want it to be EPO so you say it is EPO. That doesn't make it so.
>
You're so predictable.
Boring.
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Date: 12 Mar 2007 11:38:57
From: MagillaGorilla
Subject: Re: EPO use can cause.....DEATH!!!!
|
Kyle Legate wrote:
> MagillaGorilla wrote:
>
>>
>> For all I know they could have died from a myriad of other substances.
>> You want it to be EPO so you say it is EPO. That doesn't make it so.
>>
> You're so predictable.
>
> Boring.
Yeah, your posts are really exciting. I mean just look at it.
Thanks,
Magilla
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Date: 12 Mar 2007 02:33:11
From: Jim Flom
Subject: Re: EPO use can cause.....DEATH!!!!
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"MagillaGorilla" <MagillaGorilla@zoo.com > wrote...
>
> Yeah, you got the coroner's full report and toxicology results on that
> right? Or are you just repeating rumors you heard and claiming they are
> the same as an actual toxicology report? (Hint: no coronor tests for EPO).
>
> For all I know they could have died from a myriad of other substances. You
> want it to be EPO so you say it is EPO. That doesn't make it so.
>
> If you want to invent your own cause of death, then go right ahead. But
> don't come in here and try to sell me on the bullshit you know it's due to
> EPO when the fact is you don't.
And O.J. is innocent.
Although there is no evidence directly linking the recent spate of
fatalities to banned drug use, a similar cluster of deaths - mainly in the
Low Countries - in the late 1980s and early 1990s is now held to have ked
the arrival in cycling of the banned blood booster erythropoietin (EPO).
http://sport.guardian.co.uk/cycling/story/0,10482,1149111,00.html
Additional dangers of EPO include sudden death during sleep, which has
killed approximately 18 pro cyclists in the past fifteen years, and the
development of antibodies directed against EPO. In this later circumstance
the individual develops anemia as a result of the body's reaction against
repeated EPO injections.
http://www.rice.edu/~jenky/sports/epo.html
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Date: 12 Mar 2007 01:16:08
From: MagillaGorilla
Subject: Re: EPO use can cause.....DEATH!!!!
|
Jim Flom wrote:
> "MagillaGorilla" <MagillaGorilla@zoo.com> wrote...
>
>>Yeah, you got the coroner's full report and toxicology results on that
>>right? Or are you just repeating rumors you heard and claiming they are
>>the same as an actual toxicology report? (Hint: no coronor tests for EPO).
>>
>>For all I know they could have died from a myriad of other substances. You
>>want it to be EPO so you say it is EPO. That doesn't make it so.
>>
>>If you want to invent your own cause of death, then go right ahead. But
>>don't come in here and try to sell me on the bullshit you know it's due to
>>EPO when the fact is you don't.
>
>
> And O.J. is innocent.
>
> Although there is no evidence directly linking the recent spate of
> fatalities to banned drug use, a similar cluster of deaths - mainly in the
> Low Countries - in the late 1980s and early 1990s is now held to have ked
> the arrival in cycling of the banned blood booster erythropoietin (EPO).
> http://sport.guardian.co.uk/cycling/story/0,10482,1149111,00.html
Yeah, and all those boats that "disappear" off the coast of Florida are
due to the Bermuda Triangle. After all, what else could it be?
How do you know they didn't die of amphetamines or cocaine or mismatched
blood transfusions or Pot belge or insulin overdose or any number of
other things? Why would you just pick EPO out of the blue like that?
It's bizarre.
>
> Additional dangers of EPO include sudden death during sleep, which has
> killed approximately 18 pro cyclists in the past fifteen years, and the
> development of antibodies directed against EPO. In this later circumstance
> the individual develops anemia as a result of the body's reaction against
> repeated EPO injections.
> http://www.rice.edu/~jenky/sports/epo.html
>
A declaration without proof, names, or coroner's reports. It's all
guessing, just like you and everyone else does.
Just because you cite a link doesn't mean the content in it has been proven.
I like all the references and official documentation to support this
contention in the article (none). Do you think just because the link
has "edu" in it I'm suppose to roll over and capitulate to its content?
OJ had DNA evidence. What does your EPO contention have besides
guessing? You don't kknow any of their blood values or whether they
were anemic or not (tell me their blood's hemoglobin levels and how you
know that figure to be true).
All your evidence is self-fulfilling rhetoric.
Thanks,
Magilla
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Date: 11 Mar 2007 13:18:10
From: MagillaGorilla
Subject: Re: EPO use can cause.....DEATH!!!!
|
dupedcyclist@aol.com wrote:
> http://www.bloomberg.com/apps/news?pid=20601087&sid=aqLc.tP3A6AI&refer=home
>
> Amgen's, J&J's Anemia Drugs Get Stronger U.S. Warning (Update4)
>
SNIP
If the risk for death were so serious, surely we would have seen some
pro cyclist die from it. We haven't.
Thanks,
Magilla
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Date: 12 Mar 2007 02:53:11
From: Ryan Cousineau
Subject: Re: EPO use can cause.....DEATH!!!!
|
In article <aZidnc2xlNhPpGnYnZ2dnUVZ_vPinZ2d@ptd.net >,
MagillaGorilla <MagillaGorilla@zoo.com > wrote:
> dupedcyclist@aol.com wrote:
>
> > http://www.bloomberg.com/apps/news?pid=20601087&sid=aqLc.tP3A6AI&refer=home
> >
> > Amgen's, J&J's Anemia Drugs Get Stronger U.S. Warning (Update4)
> >
> SNIP
>
>
> If the risk for death were so serious, surely we would have seen some
> pro cyclist die from it. We haven't.
When I read this, I spit-take so hard that milk came out of my nose.
And I wasn't drinking milk!
--
Ryan Cousineau rcousine@sfu.ca http://www.wiredcola.com/
"I don't want kids who are thinking about going into mathematics
to think that they have to take drugs to succeed." -Paul Erdos
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Date: 12 Mar 2007 00:45:25
From: Callistus Valerius
Subject: Re: EPO use can cause.....DEATH!!!!
|
>
>
> If the risk for death were so serious, surely we would have seen some
> pro cyclist die from it. We haven't.
>
> Thanks,
>
>
> Magilla
---------
In Sweden, I think 4 or 5 died in their sleep from EPO. Their blood was
as thick as ketchup, and the heart just couldn't pump it. Horrible deaths,
in the early years of EPO.
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Date: 11 Mar 2007 21:35:46
From: MagillaGorilla
Subject: Re: EPO use can cause.....DEATH!!!!
|
Callistus Valerius wrote:
>>
>>If the risk for death were so serious, surely we would have seen some
>>pro cyclist die from it. We haven't.
>>
>>Thanks,
>>
>>
>>Magilla
>
> ---------
> In Sweden, I think 4 or 5 died in their sleep from EPO. Their blood was
> as thick as ketchup, and the heart just couldn't pump it. Horrible deaths,
> in the early years of EPO.
I also heard Rod Stewart swallowed a pint of sperm and had to go to the
hospital to get it pumped out of his stomach.
Thanks,
Magilla
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Date: 12 Mar 2007 10:30:01
From: Bleet Norf
Subject: Re: EPO use can cause.....DEATH!!!!
|
I heard MTV's Kennedy asked him that very question. Right towards the
end of her career.
MagillaGorilla wrote:
> Callistus Valerius wrote:
>>>
>>> If the risk for death were so serious, surely we would have seen some
>>> pro cyclist die from it. We haven't.
>>>
>>> Thanks,
>>>
>>>
>>> Magilla
>>
>> ---------
>> In Sweden, I think 4 or 5 died in their sleep from EPO. Their
>> blood was
>> as thick as ketchup, and the heart just couldn't pump it. Horrible
>> deaths,
>> in the early years of EPO.
>
>
>
> I also heard Rod Stewart swallowed a pint of sperm and had to go to the
> hospital to get it pumped out of his stomach.
>
> Thanks,
>
> Magilla
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Date: 11 Mar 2007 21:26:12
From: John Forrest Tomlinson
Subject: Re: EPO use can cause.....DEATH!!!!
|
On Mon, 12 2007 00:45:25 GMT, "Callistus Valerius"
<jazzyboss@hotmail.com > wrote:
>>
>>
>> If the risk for death were so serious, surely we would have seen some
>> pro cyclist die from it. We haven't.
>>
>> Thanks,
>>
>>
>> Magilla
>---------
> In Sweden, I think 4 or 5 died in their sleep from EPO. Their blood was
>as thick as ketchup, and the heart just couldn't pump it. Horrible deaths,
>in the early years of EPO.
There were not 4 or 5 Swedish cyclists dying in their sleep from that.
There were a number of deaths like that among racing cyclists in the
Netherlands.
--
JT
****************************
Remove "remove" to reply
Visit http://www.jt10000.com
****************************
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Date: 12 Mar 2007 08:51:04
From: Curtis L. Russell
Subject: Re: EPO use can cause.....DEATH!!!!
|
On Sun, 11 2007 21:26:12 -0500, John Forrest Tomlinson
<usenetremove@jt10000.com > wrote:
>> In Sweden, I think 4 or 5 died in their sleep from EPO. Their blood was
>>as thick as ketchup, and the heart just couldn't pump it. Horrible deaths,
>>in the early years of EPO.
>
>There were not 4 or 5 Swedish cyclists dying in their sleep from that.
>There were a number of deaths like that among racing cyclists in the
>Netherlands.
In any event, dying in your sleep isn't a 'horrible death', just
premature. I always had burning to death at the top of my 'horrible
death' list, but anything that doesn't even wake me up can't be all
that bad.
Curtis L. Russell
Odenton, MD (USA)
Just someone on two wheels...
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Date: 11 Mar 2007 04:19:08
From: MMan
Subject: Re: EPO use can cause.....DEATH!!!!
|
Fred Fredburger wrote:
> Bob Schwartz wrote:
> > Dumbass,
> >
> > Safe as orange juice, so I hear.
> >
> > Bob Schwartz
>
> Orange juice can cause death too.
So can cycling.
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Date: 11 Mar 2007 13:56:11
From: Fred Fredburger
Subject: Re: EPO use can cause.....DEATH!!!!
|
MMan wrote:
> Fred Fredburger wrote:
>> Bob Schwartz wrote:
>>> Dumbass,
>>>
>>> Safe as orange juice, so I hear.
>>>
>>> Bob Schwartz
>> Orange juice can cause death too.
>
> So can cycling.
>
Yeah, but it's hell getting the bicycles to fit through those hypodermic
needles.
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Date: 10 Mar 2007 20:54:20
From: Bob Schwartz
Subject: Re: EPO use can cause.....DEATH!!!!
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Dumbass,
Safe as orange juice, so I hear.
Bob Schwartz
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Date: 10 Mar 2007 21:20:10
From: Fred Fredburger
Subject: Re: EPO use can cause.....DEATH!!!!
|
Bob Schwartz wrote:
> Dumbass,
>
> Safe as orange juice, so I hear.
>
> Bob Schwartz
Orange juice can cause death too.
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Date: 11 Mar 2007 11:59:40
From: Donald Munro
Subject: Re: EPO use can cause.....DEATH!!!!
|
Bob Schwartz wrote:
>> Safe as orange juice, so I hear.
Fred Fredburger wrote:
> Orange juice can cause death too.
But tea is even more dangerous, particularly when combined with polonium.
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