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Date: 20 Dec 2006 07:43:06
From: gym.gravity
Subject: performance enhancement
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Resveratrol Improves Mitochondrial Function and Protects against
Metabolic Disease by Activating SIRT1 and PGC-1α
Cell, Vol 127, 1109-1122, 15 December 2006
ie Lagouge,8,1 Carmen Argmann,8,1 Zachary Gerhart-Hines,2 Hamid
Meziane,3 Carles Lerin,2 Frederic Daussin,4 Nadia Messadeq,3 Jill
Milne,5 Philip Lambert,5 Peter Elliott,5 Bernard Geny,4 kku Laakso,6
Pere Puigserver,2 and Johan Auwerx1,3,7,∗
1 Institut de G=E9n=E9tique et de Biologie Mol=E9culaire et Cellulaire,
CNRS / INSERM / ULP, 67404 Illkirch, France
2 Department of Cell Biology, John Hopkins University School of
Medicine, Baltimore, MD 21205, USA
3 Institut Clinique de la Souris, BP10142, 67404, Illkirch, France
4 Department of Respiratory, Cardiocirculatory and Exercise Physiology,
H=F4pitaux Universitaires, 67000 Strasbourg, France
5 Sirtris Pharmaceutical, Cambridge, MA 02139, USA
6 Department of Medicine, University of Kuopio, 70211 Kuopio, Finland
7 IGBMC-ICS, 67404 Illkirch, France
∗Corresponding author
Johan Auwerx
auwerx@igbmc.u-strasbg.fr
Diminished mitochondrial oxidative phosphorylation and aerobic capacity
are associated with reduced longevity. We tested whether resveratrol
(RSV), which is known to extend lifespan, impacts mitochondrial
function and metabolic homeostasis. Treatment of mice with RSV
significantly increased their aerobic capacity, as evidenced by their
increased running time and consumption of oxygen in muscle fibers.
RSV's effects were associated with an induction of genes for oxidative
phosphorylation and mitochondrial biogenesis and were largely explained
by an RSV-mediated decrease in PGC-1α acetylation and an increase
in PGC-1α activity. This mechanism is consistent with RSV being a
known activator of the protein deacetylase, SIRT1, and by the lack of
effect of RSV in SIRT1−/− MEFs. Importantly, RSV treatment
protected mice against diet-induced-obesity and insulin resistance.
These pharmacological effects of RSV combined with the association of
three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates
SIRT1 as a key regulator of energy and metabolic homeostasis.
http://www.cell.com/content/article/abstract?uid=3DPIIS0092867406014280
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=3Dpubmed&cmd=3DSearch&itoo=
l=3Dpubmed_AbstractPlus...
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Date: 20 Dec 2006 18:15:57
From: Ryan Cousineau
Subject: Re: performance enhancement
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In article <1166629386.162779.75990@73g2000cwn.googlegroups.com >,
"gym.gravity" <gym.gravity@gmail.com > wrote:
> Resveratrol Improves Mitochondrial Function and Protects against
> Metabolic Disease by Activating SIRT1 and PGC-1α
>
> Cell, Vol 127, 1109-1122, 15 December 2006
> http://www.cell.com/content/article/abstract?uid=PIIS0092867406014280
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed AbstractPlus...
Okay, are we still doing the LIVEDRUNK jersey second-line nominations?
Mine nomination is
"Resveratrol Improves Mitochondrial Function and Protects against
Metabolic Disease"
LIVEDRUNK 1, sobriety 0,
--
Ryan Cousineau rcousine@sfu.ca http://www.wiredcola.com/
"I don't want kids who are thinking about going into mathematics
to think that they have to take drugs to succeed." -Paul Erdos
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Date: 20 Dec 2006 07:45:02
From: gym.gravity
Subject: Re: performance enhancement
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Be selective about what you drink this holiday season.
Bottoms up!
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